/* ============================================
   Lung Cancer Multi-Omics Review — Custom Theme
   Rich, colorful, scientific
   ============================================ */

/* --- Base colors --- */
:root {
  --primary: #1a6b8a;
  --primary-light: #2d9cc3;
  --accent-coral: #e8655a;
  --accent-gold: #d4a843;
  --accent-teal: #2ba5a5;
  --accent-purple: #7b68ae;
  --accent-green: #4caf7d;
  --bg-light: #fafbfd;
  --bg-callout: #f0f7fb;
  --text-main: #2c3e50;
  --border-subtle: #dce4ec;
}

/* --- Page body --- */
.book .book-body .page-wrapper .page-inner {
  max-width: 900px;
  font-family: 'Inter', 'Segoe UI', system-ui, sans-serif;
  color: var(--text-main);
  line-height: 1.75;
}

/* --- Headings --- */
h1 {
  color: var(--primary);
  border-bottom: 3px solid var(--accent-coral);
  padding-bottom: 12px;
  font-size: 2.2em;
  letter-spacing: -0.5px;
}

h2 {
  color: var(--primary-light);
  border-bottom: 2px solid var(--accent-gold);
  padding-bottom: 8px;
  margin-top: 2.5em;
  font-size: 1.6em;
}

h3 {
  color: var(--accent-teal);
  font-size: 1.3em;
  margin-top: 2em;
}

h4 {
  color: var(--accent-purple);
  font-size: 1.1em;
}

/* --- Blockquotes (callouts) --- */
blockquote {
  border-left: 5px solid var(--accent-coral);
  background: linear-gradient(135deg, #fef5f4 0%, #fdf0ee 100%);
  padding: 16px 24px;
  margin: 24px 0;
  border-radius: 0 8px 8px 0;
  font-style: italic;
  color: #4a3333;
  box-shadow: 0 2px 8px rgba(232, 101, 90, 0.08);
}

blockquote strong {
  color: var(--accent-coral);
  font-style: normal;
}

/* Alternating callout styles for variety */
blockquote + blockquote {
  border-left-color: var(--accent-teal);
  background: linear-gradient(135deg, #f0fafa 0%, #e8f6f6 100%);
  color: #2a4444;
}

blockquote + blockquote + blockquote {
  border-left-color: var(--accent-gold);
  background: linear-gradient(135deg, #fdf8ed 0%, #faf3e0 100%);
  color: #4a3f22;
}

blockquote + blockquote + blockquote + blockquote {
  border-left-color: var(--accent-purple);
  background: linear-gradient(135deg, #f5f2fa 0%, #ede8f5 100%);
  color: #3d2d5c;
}

/* --- Tables --- */
table {
  border-collapse: separate;
  border-spacing: 0;
  width: 100%;
  margin: 20px 0;
  border-radius: 8px;
  overflow: hidden;
  box-shadow: 0 2px 12px rgba(0, 0, 0, 0.06);
}

table thead tr {
  background: linear-gradient(135deg, var(--primary) 0%, var(--primary-light) 100%);
  color: white;
}

table thead th {
  padding: 12px 16px;
  font-weight: 600;
  text-align: left;
  border: none;
  font-size: 0.9em;
  text-transform: uppercase;
  letter-spacing: 0.5px;
}

table tbody tr:nth-child(even) {
  background-color: #f8fafc;
}

table tbody tr:nth-child(odd) {
  background-color: #ffffff;
}

table tbody tr:hover {
  background-color: #e8f4f8;
  transition: background-color 0.2s ease;
}

table tbody td {
  padding: 10px 16px;
  border-bottom: 1px solid var(--border-subtle);
}

table tbody td strong {
  color: var(--primary);
}

/* --- Links --- */
a {
  color: var(--primary-light);
  text-decoration: none;
  border-bottom: 1px dotted var(--primary-light);
  transition: all 0.2s ease;
}

a:hover {
  color: var(--accent-coral);
  border-bottom-color: var(--accent-coral);
}

/* --- Code blocks --- */
pre {
  background: linear-gradient(180deg, #1e2d3d 0%, #253443 100%);
  border-radius: 8px;
  padding: 20px;
  box-shadow: 0 4px 16px rgba(0, 0, 0, 0.12);
  border: 1px solid #364958;
}

code {
  background-color: #eef3f8;
  padding: 2px 6px;
  border-radius: 4px;
  font-size: 0.88em;
  color: var(--accent-coral);
}

pre code {
  background: none;
  color: #d4dce4;
  padding: 0;
}

/* --- Horizontal rules --- */
hr {
  border: none;
  height: 2px;
  background: linear-gradient(to right, var(--accent-coral), var(--accent-gold), var(--accent-teal), var(--accent-purple));
  margin: 40px 0;
  border-radius: 2px;
}

/* --- Images (infographics) --- */
img {
  max-width: 100%;
  border-radius: 12px;
  box-shadow: 0 4px 20px rgba(0, 0, 0, 0.1);
  margin: 20px auto;
  display: block;
  border: 2px solid var(--border-subtle);
}

/* --- Sidebar navigation --- */
.book .book-summary {
  background: linear-gradient(180deg, #1a2332 0%, #1e2d3d 100%);
}

.book .book-summary ul.summary li a,
.book .book-summary ul.summary li span {
  color: #b8c9d9;
}

.book .book-summary ul.summary li.active > a {
  color: white;
  background: rgba(45, 156, 195, 0.2);
  border-left: 3px solid var(--accent-coral);
}

.book .book-summary ul.summary li a:hover {
  color: white;
  text-decoration: none;
}

/* --- Bold PASS/STRONG/etc in tables --- */
td:last-child {
  font-weight: 500;
}

/* --- Special markers --- */
em {
  color: #5a6b7d;
}

/* --- Infographic captions --- */
p > em:only-child {
  display: block;
  text-align: center;
  color: #7a8b9d;
  font-size: 0.9em;
  margin-top: -12px;
}